Hi all,
I have a question about running combat on microarray data.
In http://biostatistics.oxfordjournals.org/content/8/1/118.full it is said
that (3.1) 'We assume that the data have been normalized' before batch
correction.
My question is, what is intended here as normalization? Does not
normalization before batch correction distort the signal?
Thanks

~Francesco Brundu

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