Hi there,

This is the first time using combat, and i'm using it on a very large set
of data built up in 14 batches. I'm gettin many error messages when running
it, and i've searched for every single one of them in ComBat forum and
tried to fix using the information available in the forum, but i'm still
getting errors. Every time that I use tab-separeted values i get an error
saying that a I have non numerical values, then i move to .csv ant the
error changes:

Reading Sample Information File
Reading Expression Data File
Found 0 batches
Found 0 covariate(s)
Standardizing Data across genes
Error in solve.default(t(design) %*% design) :
  Lapack routine dgesv: system is exactly singular: U[1,1] = 0

or

Reading Sample Information File
Reading Expression Data File
Found 0 batches
Found 5 covariate(s)
Error in matrix(0, length(vec), nlevels(vec) - start + 1) :
  invalid 'ncol' value (< 0)

my expression file is formatted like this:

probe       lineage1       lineage2       lineage3...
xxx          11.111         22.2222        333.3333 ....
...

and my sif is like this:

ID          batch
lineage1     1
lineage2     1
lineage3     2
lineage4     3...

I'd be very grateful for any help!
thanks for your attention

Fernando

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