All,

In section 8.6.2 of the limma user's guide, an example is given using
splines for time-course data. It looks like in this example, the data
points are independent, meaning different subjects are observed at
different timepoints.

If the same subject is observed over time, is it correct to use
duplicateCorrelation function along with the spline model. Is this the
correct way to handle profiles of individuals in limma?

What other Bioconductor approaches have people used? I can't tell if EDGE
(Leek and colleagues) is updated/maintained.

Thanks,

Juliet

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