On Thu, Mar 14, 2013 at 10:56 AM, Feng Tian <fengtian@bu.edu> wrote:

> Hi All,
>
> I do Gene Set Enrichment Analysis to two data set from GEO of the same
> disease. I find that enriched gene sets of two data set have an overlap at
> only about 60%. I am a new guy to analyze Microarray data. Is this a
> reasonable results? What are the potential reasons of these differences,
> since two data set are for the same disease?
>

Hi, Feng.

This sounds reasonable, yes.  There are many potential differences
including biological variability, technical variability, disease
heterogeneity,  and platform differences, to name a few.

Sean

	[[alternative HTML version deleted]]

