Hi,


I am currently analyzing the expression data from Glioblastoma samples provided by the TCGA. As an additional validation data set I downloaded a collection of Affymetrix cel files. For better comparability I would like to use the same probeset mapping as TCGA did for their chips. 
For this purpose, a so called ADF [array description file] is supplied (https://tcga-data.nci.nih.gov/tcga/tcgaPlatformDesign.jsp). It contains the probeset ID, the chromosomal location and the NCBI gene ID. I have previously used costum CDF files for the normalization of Affy cel files. I am now wondering how I can use the information from the ADF file for the normalization process. Do I have to convert the ADF file to a CDF file first? Or is there some way to re-map a already available CDF file?


Thank you very much,



Christoph








	[[alternative HTML version deleted]]

