Dear Chris,

	Limma can be used to test between time points
treating each time point as a categorical variable.
The program "EDGE" from the Storey lab, can test whether
there is significant change over a whole time course.

http://www.ncbi.nlm.nih.gov/pubmed/16357033

with hopes that the above helps,
Rich
Richard A. Friedman, PhD
Associate Research Scientist,
Biomedical Informatics Shared Resource
Herbert Irving Comprehensive Cancer Center (HICCC)
Lecturer,
Department of Biomedical Informatics (DBMI)
Educational Coordinator,
Center for Computational Biology and Bioinformatics (C2B2)/
National Center for Multiscale Analysis of Genomic Networks (MAGNet)/
Columbia Initiative in Systems Biology
Room 824
Irving Cancer Research Center
Columbia University
1130 St. Nicholas Ave
New York, NY 10032
(212)851-4765 (voice)
friedman@cancercenter.columbia.edu
http://cancercenter.columbia.edu/~friedman/

"Complex numbers! Ha! Ha! There is nothing weirder
than imaginary numbers. Architects don't need to know 
complex numbers. Whenever I get a  negative root for
an area, I throw it out. And don't talk to me about
quaternions. I am not going into computer animation."
-Rose Friedman, age 16
 

On Jan 30, 2013, at 11:43 PM, chris Jhon wrote:

> Hi All,
> 
> I have data at different time points for time course experiment.
> I have a response for each time point and i would like to test whether the
> difference between response of two time points is statistically significant
> or not.
> my data is linear plot where response on y axis and time on x axis.
> 
> what statistical test shall i use?
> 
> 
> I appreciate any help.
> 
> Best Regards,
> Chris
> 
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> 
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