I hate to say this. However, to be honest, I don't think those papers are very helpful for biologists.




________________________________
 From: Wolfgang Huber <whuber@embl.de>

Cc: "bioconductor@r-project.org" <bioconductor@r-project.org> 
Sent: Saturday, December 15, 2012 10:02 AM
Subject: Re: [BioC] linear models for microarray and RNA-seq

Dear Xin

the accompanying papers and package vignettes might be a good place to start.
The authors of these packages have put a lot of effort in these, you could check them out.

    Best wishes
    Wolfgang


ha scritto:

> Limma and EdgeR both used linear models to fit the data. Anyone could explain the differences between these two linear models? I noticed Limma requires normal data and edgeR needs negative binomial distribution.
> 
> Thanks.
> 
> Xin
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