Hey Simona, 

Thanks for your email. This is a difficult question. If the number of samples and number of miRNAs in the data are large, then I think it would be safe to apply ComBat to the data. The non-parametrix prior option might be best. For small sample or miRNA sizes, I don't think there is a good tool out there at the moment.

I'd be interested to see how it works on your data. Thanks! 

Evan



On Nov 12, 2012, at 3:45 PM, Simona Rossi wrote:

> Hello,
> 
>     I'm Simona and I'm a Bioinformatician.
> 
> I'm studying some miRNASeq data that are affected by a
> strong batch effect, in your opinion, ComBat might be
> applied to miRNASeq data?
> 
> Thank you very much in advance,
> 
> Best Regards,
> 
> Simona Rossi
> 
> -- 
> --
> Dr. Simona Rossi
> Bioinformatician
> 
> SIB | Swiss Institute of Bioinformatics
> 
> Quartier Sorge
> Bâtiment Génopode
> CH-1015 Lausanne
> Switzerland
> 
> simona.rossi@isb-sib.ch
> www.isb-sib.ch
> 


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