Dear listers,

 

I would like to apply the Differential Methylation Region Algorithm (DMRA) to a set of Illumina 450K methylation arrays. I have already normalized my data using SWAN (package minfi), and now I would like to apply the dmrFinder function (charm package) to this normalized dataset. However, the dmrFinder function needs an object of class TilingFeatureSet as input, but I only have a MethylSet object returned by minfi.

 

I would be grateful if anyone could point me about how I could apply this method to my 450K normalized dataset.

 

Thank you so much for your help in advance.

 

Best regards,

 

Xavi.

 

------

Xavier Solé Acha

Unitat de Biomarcadors i Susceptibilitat

Unit of Biomarkers and Susceptibility

Institut Català d'Oncologia // Catalan Institute of Oncology

Av. Gran Via de L'Hospitalet 199-203

08908 L'Hospitalet de Llobregat, Barcelona, Spain.

Phone: +34 93 260 71 22 / +34 93 260 71 86 (ext. 7122)

Fax: +34 93 260 71 88

E-mail: x.sole (at) iconcologia.net

 


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