Dear all,

would appreciate any suggestions on the following problem : how to correct
for the changes in the basal level of gene expression, when comparing 2
conditions : let's say :

a gene changes from 100 to 200 in response to hormone (fold change =2)
the same gene changes from 150 to 250 in response to the same hormone, but
a protein in the cell is knock-down in the experiment (fold change = 1.6)

would need a procedure to correct for the changes in the basal level (100
to 150) in the experiments for a set of genes. any suggestions - perhaps
using some scaling factors ? thanks !

b

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