Hi,
We are analyzing our first methylation dataset (Illumina 450k array).
Through minfi I am able obtain a list of differential methylated probes (CGxxxx), but I would like to place these in a genomic context. Unfortunately I don't have any hands-on experiences with genome analysis (genomic localization, closest transcript/gene, generating input for genome browser, etc.) so I would appreciate if someone could point my to a workflow that allows these type of analysis starting from a list of probes. I know packages such as GenomicRanges and GenomicFeatures likely can be used for this, but whether these are really the best options, and if so, the exact order/way isn't clear to me yet. Hence, any suggestion is appreciated.

Thanks in advance,
Guido
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Guido Hooiveld, PhD
Nutrition, Metabolism & Genomics Group
Division of Human Nutrition
Wageningen University
Biotechnion, Bomenweg 2
NL-6703 HD Wageningen
the Netherlands
tel: (+)31 317 485788
fax: (+)31 317 483342
email:      guido.hooiveld@wur.nl
internet:   http://nutrigene.4t.com
http://scholar.google.com/citations?user=qFHaMnoAAAAJ
http://www.researcherid.com/rid/F-4912-2010


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