On Tue, Sep 11, 2012 at 10:47 AM, Aaron Mackey <mackey@hemoshear.com> wrote:

> the models we use don't really test/allow for such "binary" switching
> behavior (i.e. infinite fold changes)


By the way, has anyone considered/tried composing a mixture model (i.e.
zero-inflated negative binomial) to deal with such?  I don't mean to handle
the overdispersion in counts, but to explicitly model the differences
between inferences of "no counts because no RNA" vs. "no counts because RNA
too rare to sample, but let's estimate the abundance anyway".

cf. http://www.ats.ucla.edu/stat/r/dae/zinbreg.htm

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