Val Obenchain can reply more definitively, but, briefly, VariantAnnotation
package has a scanVcf capability that
allows survey of vcf archives with managed memory consumption.  If you do
not see enough details in the vignette
to solve this use case efficiently, let us know.

On Tue, Jul 17, 2012 at 10:53 AM, Timothy Duff <timothy.duff@ncf.edu> wrote:

> Hi. I have a set of rsIDs for which I'm interested in obtaining allele
> frequencies for (in a particular population surveyed by 1kGP.) The
> corresponding .vcf files are pretty memory consumptive. Do there currently
> exist basic BC tools that could help with this sort of thing? Thank you all
> for your consideration.
>
> --
> Tim
>
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