Hi James

Thanks a lot, i thought so as well.

Its two sided

Thanks again
yours,
Alyaa

On Wed, Jul 11, 2012 at 4:21 PM, James W. MacDonald <jmacdon@uw.edu> wrote:

> Hi Alyaa,
>
>
> On 7/11/2012 2:59 AM, Alyaa Mahmoud wrote:
>
>> Hi All
>>
>> Is there a way to determine expression status of a gene (up, down) from
>> corrected p.values ?
>>
>
> No. The p-values are strictly between 0 and 1, so there is no way to
> discern the sign of the underlying t-statistic. This would not be true if
> you were doing a one-sided t-test, but I can't imagine a use case for a
> one-sided t-test in the context of microarray analysis.
>
> Best,
>
> Jim
>
>
>
>
>> Thanks a lot
>> Alyaa
>>
>>
> --
> James W. MacDonald, M.S.
> Biostatistician
> University of Washington
> Environmental and Occupational Health Sciences
> 4225 Roosevelt Way NE, # 100
> Seattle WA 98105-6099
>
>


-- 
Alyaa Mahmoud

"Love all, trust a few, do wrong to none"- Shakespeare

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