Hi,

I am working on a multifactor analysis using DESeq.  When I call estimateDispersions I get the following error:

cdsFull <- estimateDispersions( cdsFull, method="pooled-CR", modelFormula = count ~ sample+allele+allele:diet)
Error in glm.fit(mm, y, family = MASS::negative.binomial(initialGuess),  : 
  NA/NaN/Inf in foreign function call (arg 1)

Could someone please tell me what the meaning of this error is.  My design works well on my mock dataset, but with other experimental datasets having the same structure as the mock it throughs this error.  Thus, it must result from something in the data.

Thank you for your help.

best wishes,
Chris






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