Dear
colleagues,


We would like to introduce a new tool called “CU-DREAM” for intersecting two
microarray datasets. CU-DREAM compares the datasets of two microarray
experiments (reported in http://www.ncbi.nlm.nih.gov/geo) with different conditions to determine if the two conditions
share genome wide gene regulation pathway. CU-DREAM is an effective tool for
the pre-screening of drugs, substances or environmental insults or the
identification of the genetic changes that are associated with pathological
conditions. For more information please find the CU-DREAM article at http://abm.digitaljournals.org/index.php/abm/article/view/589/431

CU-DREAM(X) can intersect a GSE dataset with “a gene
set.” This program is designed to find the association between up or down
regulation of certain GSE microarray experiments and a group of certain genes.
Example of CU-DREAM(X) comparing gene expression and gene containing intragenic
LINE-1 (long interspersed nuclear element-1) can be found at http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0017934

All materials (executable file, user manual, examples)
can be downloaded at the project homepage: http://pioneer.netserv.chula.ac.th/~achatcha/cu-dream

Please reference CU-DREAM and CU-DREAM(X) as follow.

Aporntewan C, Mutirangura A. Connection Up- and Down-Regulation Expression
Analysis of Microarrays (CU-DREAM): A physiogenomic discovery tool, Asian
Biomedicine, Vol. 5 No. 2, pp. 265-270, April 2011. DOI:
10.5372/1905-7415.0502.034.

Aporntewan C, Phokaew C, Piriyapongsa J, Ngamphiw C, Ittiwut C, Tongsima S,
Mutirangura A (2011) Hypomethylation of Intragenic LINE-1 Represses
Transcription in Cancer Cells through AGO2. PLoS One 6 (3):e17934.
doi:10.1371/journal.pone.0017934

Best Regards,

Prof. Apiwat Mutirangura, Center for Excellence in Molecular Genetics of Cancer
and Human Diseases, Department of Anatomy, Faculty of Medicine, Chulalongkorn
University, Bangkok 10330, Thailand.

Asst.Prof. Chatchawit Aporntewan, Department of Mathematics, Faculty of
Science, Chulalongkorn University, Bangkok
 10330, Thailand. 
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