Hi Maria,

You will need to post a link to a webpage or some such, the list software
strips out attachments.  Also your sessionInfo() and any preceding data
manipulations that might have been involved would be very helpful.

If it's what I think it is, then yes, I've seen it before.

--t


On Wed, Jun 22, 2011 at 8:05 AM, maria giulia bacalini
<mugiu17@hotmail.com>wrote:

>
> Hello everybody,
>
> I'm very new of R and Infinium methylation analyses.
> I'm trying to analyze beta-values from an experiment performed by a
> collegue on Infinium 450k platform.
> When I plot the distribution of the beta-values, I achieve a distribution
> with 3 peaks: 1 around 100% methylated (expected), and 2 around respectively
> 0 and 10% methylation, like in the figure attached. I expected only a peak
> in this region, i.e. a bimodal distribution. Do you think this could be a
> normalization or techinical bias? Has anyone ever observed something
> similar?
>
> Thank you in advance,
> MGiulia
>
>
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>


-- 
If people do not believe that mathematics is simple, it is only because they
do not realize how complicated life is.
John von Neumann<http://www-groups.dcs.st-and.ac.uk/~history/Biographies/Von_Neumann.html>

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