I must be dense, because I can't seem to figure out how a person would use
limma to fit a linear mixed model.  Is this because doing so would involve
trying to do a Cholesky decomposition on a huge-by-huge matrix, and likely
lead to flames shooting out the sides of my computer?

Seems like a relatively straightforward thing to do but most challenging
problems appear that way.  Should I stick to trying lme4 for this purpose?
 It seems a shame not to regularize with eBayes.

-- 
If people do not believe that mathematics is simple, it is only because they
do not realize how complicated life is.
John von Neumann<http://www-groups.dcs.st-and.ac.uk/~history/Biographies/Von_Neumann.html>

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