Hi,
Let me explain the issue clearly.I have taken the agilent 4x44 array series
matrix file from geo and removed the above information except the expression
data with ids in row 1 and column1 with GSMs.I am trying to normalise it
with cyclic loess method.

exprs <- as.matrix(read.table("GSE__.txt[1]", header = TRUE,sep = "\t",
row.names = 1, as.is = TRUE))

then to normlize i used

normalize.loess(exprs,epsilon=1,log.it=F,span=0.4,maxit=2)

when I am doing this it doesnot show any error but my system shuts down.I
guess this is because it is too much of processing.So is my method correct
or should I have to break it and analyze if so how do I do it?

I hope it is clear now.

Thank you in advance,

Viritha

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