
Hello BioC,

   I have a quick question about the proper way to normalize arrays using gcrma. Right now I have a time series array, basically 10 groups in total, each group has 2 replicates. The groups refer to time 0 (control), time 1,2,4,6,10,12...etc. 

   When I normalize these cel files, should I normalize them together as one group, or should I perform separate normalizations on each of the groups (i.e. perform 10 separate normalizations on each of the 10 groups)?

 

Thank you!

Sincerely,

Casper
 		 	   		  
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