Dear all,
 
Currently，we are working with Affymetrix u133plus2 array and interested in classification disease/control using microarray data.
 
We have identified a molecular signature and trained a svm-based classification model based on 200 samples (100 disease +100 control). We are satisfied with the model performance (sensibility/specificity) evaluated with cross validation process. Now we are planning to evaluate the model performance on an independent dataset.
 
I have been asked to estimate sample size required for a given target sensibility/specificity. So I would like to know is there any general approach (paper or software) existed to deal with sample size estimation for independent validation set.
 
Any help will be greatly appreciated,
 
Thanks in advance,
Qinghua 



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