It looks like Biostrings function "writeFASTA" overwrites the output file at each run.
It seems it does not support the "append" parameter.
 
I have to generate one big file gathering a miRNA identifier and relative sequence followd by a variable number of  dara records pertaining such a miRNA  target genes transcription. 
Each record is made up of  a 3'utr identifier <hgnc_id>.<ensembl_id>.<transript_id>
followed by the relative 3'UTR sequence.
 
I hoped I could use writeFASTA but it does not allow me to append sequences to the same output file.
Any suggestion is more than welcome.
 
Thank you in advance,
Maura



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