RECONSTRUCTING NETWORKS FROM TIME-RESOLVED METABOLOMICS DATA

We offer a 4 year PhD or 3 year postdoctoral position in the field of
systems biology, specifically on the interface of biological networks
and metabolomics. This vacancy is funded by the Netherlands Metabolomics
Centre (www.metabolomicscentre.nl), a multidisciplinary combination of
groups dedicated to develop metabolomics technologies and to incorporate
the emerging tools into biological/biomedical research.

We are looking for candidates with a masters degree and/or a PhD in the
natural sciences with a strong mathematical component.  A genuine
interest and/or experience in biology is appreciated. The  ability to
work across disciplines is mandatory for such systems biology projects. 

Description:

A crucial part of any biological systems is its metabolic network.
Reconstruction of biological networks is an important topic in systems
biology.  In this project, we will develop methods to reconstruct
metabolic networks from real  and  in-silico time-resolved metabolomics
data.  The reconstructed metabolic networks will improve insight in the
molecular functioning of a cell or an organism.  Moreover, such networks
might reveal disease progression, efficacy of treatments, effects of
interventions and explain phenotypic variation.   

In the last few years many network modeling methods have become
available. These methods mainly aimed at reconstruction of gene
regulatory networks and protein-protein interaction networks. Only
recently effort has been put in the development of methods to infer
metabolic networks working with small metabolic systems. Problems occur
for reconstructing large metabolic networks. This calls for new network
inference algorithms that optimally use the time-resolved metabolomics
data and can work for large systems. 

 

For more information call dr. M.M.W.B. Hendriks, +31 88 7553705 or dr.
H.C.J. Hoefsloot, +31 20 5255867. You can email a CV and cover letter to
m.hendriks-9@umcutrecht.nl

 


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