On Mon, Nov 24, 2008 at 10:43 PM, Amin Momin <gtg269c@mail.gatech.edu>wrote:

> HI,
>  I am interested in knowing if it is advisible to combine microarray data
> from the dame platform for different cell lines for normalization and
> analysis. Recently I noticed that this was done at the Genomic foundation of
> novartis web portal for the NCI60 cell lines. They have merged NCI60 cell
> data with another 40 cancer cell lines. I was wondeing if some some has
> experience with this and under what condition will this be a valid protocol.
>

Hi, Amin.

This is generally not advisable as lab-to-lab and other technical variation
is typically a significant factor.

Sean

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