Dear all,

We have a number of research and programming positions available in
Computational biology and Bioinformatics:


The Paterson Institute for Cancer Research in Manchester is a leading cancer
centre of excellence core-funded by Cancer Research UK, the largest
independent cancer research organisation in the world. The Institute
supports numerous basic and translational cancer research programmes and has
a wide range of state-of-the-art research services. It is located adjacent
to the Christie Hospital, a specialist cancer hospital, thereby ensuring
ample opportunities for interaction across the basic to clinical research
spectrum. The Institute is also at the heart of the newly formed Manchester
Cancer Research Centre (MCRC).

A number of positions are available within the Applied Computational Biology
Group for scientists interested in joining a multidisciplinary team and
using the latest in high throughput technology to further our understanding
of cancer.


Post 1:  Postdoctoral Researcher

Recent work has shown that a significant proportion of the human genome is
transcribed, and that a substantial fraction of this non-coding RNA plays a
functional role within cells. We are seeking a postdoctoral research
scientist with a PhD in computational biology (or a related discipline), to
investigate the behaviour of these genomic regions in cancer. The successful
applicant will work in collaboration with both clinical- and
basic-scientists on research involving new technologies including next
generation sequencing and high density tiling microarrays. The project will
involve analysing genome wide data generated from a mixture of clinical and
cell-line samples, with a focus on non-coding RNA and its interactions with
other molecules. The goal is to indentify new players in the regulation and
control of cancer.

Post 2: Postdoctoral Researcher

We are seeking a postdoctoral scientist to analyse high throughput clinical
microarray datasets. The post will involve working as part of a
multidisciplinary international collaboration investigating patient outcome,
and will involve dealing with large quantities of Affymetrix Exon microarray
data. The successful applicant will have a PhD in computational biology (or
a related discipline), be statistically adept, and have significant
experience interpreting gene expression data. Strong communication skills
are essential, as is a desire to generate software tools and approaches with
direct practical applications. The goals are (i) to indentify novel sets of
genes that can be used to help support patient diagnoses and (ii) to develop
and validate real time PCR based approaches with which to apply these gene
sets in the clinic.


Post 3: Computer programmer

We are looking for a computer programmer with a strong background in Java
and/or C who is inspired by science and technology and enjoys exploring new
programming languages and techniques.

The successful applicant will be interested in learning about the human
genome and the role it plays in cancer. The post will involve developing new
software tools for the analysis of genome-scale data generated using a
variety of technologies, including high throughput sequencing, mass
spectrometry and high density tiling microarrays. For this position,
detailed biological knowledge is less critical than excellent programming
skills, creative problem solving, and the ability to communicate well with
scientists and researchers from different disciplines. You will be qualified
to degree level in computer science or a related discipline.

For posts 1 and 2, the deadline for receipt of applications is the 4th
December, for post 3, the 26th November.

For more details, see our website at www.paterson.man.ac.uk.

Best wishes,
Crispin 
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