Dear list,

I have a question about gene expression data normalization which is
related to batch effect.

The dataset which I am interested appear to be collected in several
batches. Apparently, these batches were generated at varied time
points.

So my question is that whether I should pull all arrays (cel files) together
and normalize or I should normalize arrays within batch and then concatenate
them into a single file.

Thank you very much for your help!

Sincerely,
     Allen

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