We have a postdoctoral opportunity at the EPA research facility in 
Research Triangle Park, NC. 

Molecular Modeling for Risk Assessment

We are seeking a highly motivated individual with expertise in data mining 
and the analysis of high-volume data sets (e.g., microarray, proteomics) 
to support existing efforts in building biologically based dose-response 
(BBDR) and other mechanistically based models for use in risk assessment. 
Duties associated with this position include the following. 
1.  Analysis of high-throughput data to predict the mode of action for 
toxicants. This will include identification of bioindicators significantly 
associated with toxic effects based on one or more of the following data 
types: microarray, proteomics, metabolomics, SNP genotyping, and CHIP-seq 
(DNA methylation, chromatin, and transcription factor binding). In 
addition, the candidate will be responsible for generating data-driven 
biological networks using the data referenced above along with 
protein-protein interaction data extracted from public databases. The goal 
of these studies would be to determine measureable key events appropriate 
for describing the mode of action in a BBDR model. 
2.  Work with collaborating laboratories to design experiments to support 
key event discovery and BBDR modeling efforts. The candidate will be 
responsible for insuring that the experiments including high-throughput 
data collection are sufficiently powered to enable the activities outlined 
in section 1. In addition, the candidate will be responsible for insuring 
that data generated to support BBDR modeling will be sufficient to support 
a quantitative deterministic model for the mode of action of environmental 
stressors. 
3.  Work with modelers in developing BBDR models. While this position will 
not require the candidate to produce deterministic models of environmental 
stressors, the candidate will work closely with others in building these 
models. Based on the candidate’s background and interest, some modeling 
work may be included as appropriate to the project. 
Opportunities exist for investigation of both air and water toxicants with 
toxic effects ranging from cardio-vascular disease to cancer.

For more details, please consult the following URL:
http://cfpub.epa.gov/nheerl/index.cfm?fuseaction=postdocs.main

Thanks,
Steve
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Stephen W. Edwards, Ph.D.
Systems Biologist, ADHIO, NHEERL, ORD, USEPA
U.S. Environmental Protection Agency
109 TW Alexander Drive (B305-01)
Research Triangle Park, NC  27711
Ph#: 919/541-0514       FAX#: 919/685-3221

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