Dear All,

Our lab processed 3 chips (control condition) first and then after a month
processed one more chip (control condition). It is the same story for the
treatment condition, 3 chips first and then later added one more. The
laboratory procedures are fairly the same for both the time. Now, the
question is: how do we analyze such data? Is it a good to normalize all the
chips together? We greatly appreciate any thoughts on this issue.

Thanks in advance.

Kind regards,
Sharon

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