Dear Friends,

I am trying to use some supervised method to identify the genes which permit
the separation of two patients conditions.

Due to the extreme difficulty, I can only have the test set (about 17
patients), could I just use these 17 data sets as training set as well as
test, such as using leave one out cross validation?
I know its result may be optimistic, but I am just wondering:

1. if you have any good idea about  this  small sample size issue in
classification analysis.
2. is the cross-validation a legitimate method to support that I have
identified the genes which can separate the groups as different conditions?
we try to get this result published, will it be an OK as using this
cross-validation?
3. what packages, methods, will you recommend for this issue?

Thanks.


Regards,
-Roger

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