  Dear List,
  I have posted a similar question before, but would like to ask you again
  about filtering strategies. I have some AB1700 data and filter on signal to
  noise ratios before normalization. The rationale is to get rid of badly
  measured signals before actual processing of the data. Two jpg histograms of
  log2 signal distributions, before (raw.jpg) and after (filtered.jpg)
  filtering, can be seen in this location:
  http://tmgarden.cloud.prohosting.com/images/
  Could you please have a look at the distributions and comment on whether
  this is correct to filter before normalization as this changes the distribution of
  signals a lot?
  Thank you very much for your help.
  Lev.

       
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