We have an opening in the genomics/bioinformatics group within translational science department. We are looking for a highly motivated scientist to bring new expertise and cutting edge technologies to our group. Your major duties and responsibilities are:
  1. Able to use Transfec (or other cis element databases) and commercially available software packages (that use Gibbs Sampler, Hidden Markov Model, Log odds ratio approach, etc) to identify genes that have overrepresentation of desired cis-elements in the promoter regions based on results from expression array or promoter array;
  2. Familiar with major classification tools used in miroarray field for disease classification - Artificial Neuron Network, Support Vector Machine, K nearest neighbor, Binary classification, Linear Discriminant Analysis, Principal Component Analysis, Multidimensional Scaling, etc. You must be able to work actively with biostatisticians to apply these tools to help in discovery and translational research;
  3. Able to use Bioconductor modules to analyze internally generated and public domain microarray data on cancer, autoimmune diseases and infectious diseases to generate candidate biomarkers that can be validated to use in clinical trials, and potential new therapeutic targets; 
  4. Able to use state of the art approach (Bayes Network, etc) to identify statistically significant pathways altered in diseases based on genomics/proteomics data;
  5. Work with scientists within research and clinical development team to design the best genomics approach to address specific questions in clinical and preclinical studies;
  Job Requirements:
  · PhD in life science or computational biology;
  · Minimum 5 years of relevant experience;
  · Familiar with Affymetrix genechip technology (experience with SNP array and/or promoter array is highly desired);
  · Strong expertise in microarray datamining using bioconductor R, Spotfire;
  · Perl and basic Unix programming skills desired;
  · Familiar with cis-element analysis/promoter analysis tools; 
  · Familiarity with drug discovery process is highly desired;
  · The ability to interact in a cross functional environment is desired.
   
  For those who are interested, please send you cv and cover letter to yaoy@medimmune.com.
   
  MedImmune, Inc. is an Equal Opportunity Employer and does not discriminate on the basis of race, color, religion, gender, age, national origin, disability, veteran status, or any other characteristic protected by federal, state or local law.

