We are using the newest version of Bioconductor (1.9) to perform an Affy microarray analysis on some mouse chips.  When we start using the "expresso" command to normalize the signal intensity, we get the following error statement:

"mkdir: "/usr/local/R-2.4.0/lib/R/library/00LOCK": Permission denied
ERROR: failed to lock directory '/usr/local/R-2.4.0/lib/R/library' for modifying

The downloaded packages are in
        /tmp/Rtmpi41v2y/downloaded_packages
Error in getCdfInfo(object) : Could not obtain CDF environment, problems encountered:
Specified environment does not contain Mouse430_2
Library - package mouse4302cdf not installed
Data for package affy did not contain mouse4302cdf
Library - package mouse4302cdf not installed
In addition: Warning messages:
1: installation of package 'mouse4302cdf' had non-zero exit status in: install.packages(cdfname, lib = lib, repos = Biobase:::biocReposList(),  
2: cannot create HTML package index in: tools:::unix.packages.html(.Library)" 

We downloaded "mouse4302cdf_1.12.0.tar.gz", but we cannot install it.  We tried to use the following R commands to install this package:

install.packages("mouse4302cdf")
install.packages2("mouse4302cdf")
attach(mouse4302cdf)
biocLite("mouse4302cdf")

We also tried installing the "getBioC" package from the www.bioconductor.org/download   .

Thank you for your help.



	[[alternative HTML version deleted]]

