

Hello all,

I work  for a in vitro diagnostic company (www.biomerieux.com) and we are interessed in classification of microarray data.

We have identified a molecular signature based on a custom array and we
are planning to evaluate the performance of this signature on a large
scale.

I have been asked to estimate sample size requirements for a given target
sensibility/specificity and I can't find papers or tools dealing with it
except on paper focused on sample size estimation when using Linear
Discriminant Analysis. So I would like to know if someone hear about a
general approach (paper or software) to deal with sample size estimation
for microarray data classification or model performance evaluation.

Any help will be greatly appreciated,

Thanks in advance,

Malick Paye | bioMérieux | Biomathematician
Phone: (+33)4 78 87 70 97 | Fax: (+33)4 78 87 53 40
[Parc Polytec, 5 Rue des Berges, 38004 Cedex 01  Grenoble, France]


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