  Hi, Everybody,
   
  Come here for need your next help and support!. Thanks in advance.
   
  Previous meta analysis of combining multiple microarray studies always focuses on the cancer sample vs normal sample, not on tumor, normal or cell line versus a “common reference” sample.
   
  Of microarray datasets I collected, some predominantly are cancer versus normal, some as below: each experimental sample (tumor, normal or cell line) was assayed versus a “common reference” sample that was a pool of total RNA derived from 30 of the tumor samples. I want to estimate the difference in expression of a tumor versus normal comparison. Would you like to give me some advice of how to use the datasets of experimental sample versus a common reference sample into meta analysis ?
   
  I am looking forward to your reply.



Best Regards
 
Han Weinong  
hanweinong@yahoo.com

		
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