Hi BioC,

I have a data set from an experiemnt that has a control and a treatment group for a total of 8 dogs. Each group has 4 bioloigical replicates (4 dogs). Animals are in pairs in terms of siblings. Is paired test appropriate in this case?

Due to low replicate number (4), is traditional t test appropriate? If not, what would be other options in BioC packages besides SAM? 

Thanks in advance!
Johnny


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