Hello all,
I am working a microarray data set of 285 affy.These 285 slides are from 16 
different groups(16 subgroups of AML).And I want to find the signature genes 
for each group(for molecular classification).So i have two options:

   1. using the SAM muti class function to get the signature genes 
   simultaneously 
   2. using the unpaired two class function for each group,.For a 
   particular group,sample from this group is a class,and sample from all other 
   groups as another class.That is to say,i need to perform SAM two class 
   function 16 times.
    
My question ,what's the difference,which is better.
Thank in advance.
Xiao Shi

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