[BioC] Using EdgeR to test for null ratios other than 1:1

[Emily [guest]]

I was wondering whether I could use EdgeR to test for differences between two groups with an inherent bias in their reads proportional to each other. By this I mean that instead of each gene being tested with the null of 1:1  could I modify edgeR to test for a gene where the null is say 1.5:1 and another gene with a null of 3:4 etc.

Many thanks in advance,

Emily

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