[BioC] Using DESeq to test for null ratios other than 1:1

[Emily [guest]]

I was wondering whether I could use DESeq to test for differences between two groups with an inherent bias in their reads proportional to each other. By this I mean that instead of each gene being tested with the null of 1:1  could I ask the program to test for a gene where the null is say 1.5:1 and another gene with a null of 3:4 etc. It would be useful to input a list of null ratios for a list of genes.

Many thanks,
Emily

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