[BioC] On empirical Bayes of edgeR

Gordon K Smyth smyth at wehi.EDU.AU
Sun Nov 10 11:47:07 CET 2013

Dear Bin Zhuo,

I answered this question when you mailed it to me individually. There is 
no need to send duplicate emails.


Professor Gordon K Smyth,
Bioinformatics Division,
Walter and Eliza Hall Institute of Medical Research,
1G Royal Parade, Parkville, Vic 3052, Australia.

> Date: Thu,  7 Nov 2013 12:32:45 -0800 (PST)
> From: "Bin Zhuo [guest]" <guest at bioconductor.org>
> To: bioconductor at r-project.org, zhuob at stat.oregonstate.edu
> Subject: [BioC] On empirical Bayes of edgeR
> Dear all,
> Recently I'm reading the paper "Moderated statistical tests for 
> assessing differences in tag 
> abundance"(http://bioinformatics.oxfordjournals.org/content/23/21/2881.full.pdf+html).
> In part 3.2 where the estimation algorithm was stated, I have trouble 
> understanding ALGORITHM STEP (3). My question was, How does the equation 
> in STEP (3) relate to that in equation (4), the one right above this 
> paragraph?  I'm confused especially by the denominator( 
> I_g(1+I_g\tau_0^2) )in the bracket.  Is there any reference about on 
> this particular point?
> Thanks,
> Bin Zhuo
> -- output of sessionInfo():
> None
> --
> Sent via the guest posting facility at bioconductor.org.

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