On Feb 5, 2013, at 4:02 AM, Gordon K Smyth <smyth at wehi.edu.au> wrote: > Dear Rich, > > I have added a time course example using splines to the limma User's > Guide, see page 48: > > http://bioconductor.org/packages/2.12/bioc/vignettes/limma/inst/doc/usersguide.pdf > What if multiple conditions are available? d