[BioC] Apply non-Gaussian distribution data to limma

[Jiang [guest]]

Hi,
I have high through array data with two peaks in its distribution (raw and log 2 transformed). I googled it looks like is mixed Gaussian distribution - two normal distribution as some people suggested. I think limma's assumption is normal distribution. I was wondering if there is any way to fix the problem or to convert my data to normal distribution before applying to limma.

Thanks,
Jiang

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