[BioC] normalization method & dispersion estimation RNA-seq data
Ryan C. Thompson
rct at thompsonclan.org
Mon Nov 26 21:35:39 CET 2012
It doesn't seem that the Wald test is compensating for anything, since
the authors show that putting their dispersion estimates into edgeR
causes it to produce nearly identical results.
On 11/26/2012 10:24 AM, Tim Triche, Jr. wrote:
> The supplement mentioned by the authors in their final paragraph is also
> attached (here). It is worth at least a glance. I wonder whether the
> notoriously anticonservative Wald test is responsible for recovering
> information lost to over-shrinkage.
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