[BioC] Newbie. quantile normalization should be done on all conditions or within replicates of each condition?

[Cytochalasin]

Hi all!

Newbie here.

I wondered wh ether quantile normalization should be done on an array
containing all conditions of 1 experiment (eg containing both patients
and healthy people) or within replicates of each condition (eg on data
from patients and on data from healthy people separately)?

Thanks indeed.