[BioC] edge-less pathways in graphite
Hamid Bolouri
hbolouri at fhcrc.org
Wed Apr 25 20:03:50 CEST 2012
hi; I am finding that some KEGG pathway graphNELs generated by graphite have zero edges, even though the KGML description includes edges, e.g.
> kegg[["ErbB signaling pathway"]]
"ErbB signaling pathway" pathway from KEGG
Number of nodes = 87
Number of edges = 0
Type of identifiers = native
Retrieved on = 2011-05-05
Whereas the KGML for the same pathway includes statements such as:
<relation entry1="75" entry2="46" type="PPrel">
<subtype name="activation" value="-->"/>
<subtype name="phosphorylation" value="+p"/>
</relation>
Am I missing something?
Thanks for a great package, BTW!
Hamid Bolouri
PS Of the 46 apparently edge-less graphite graphNELs, several have zero edges in KEGG also, e.g. kegg[["Spliceosome"]]. I am _not_ talking about those.
> sessionInfo()
R version 2.15.0 (2012-03-30)
Platform: i386-pc-mingw32/i386 (32-bit)
locale:
[1] LC_COLLATE=English_United States.1252 LC_CTYPE=English_United States.1252
[3] LC_MONETARY=English_United States.1252 LC_NUMERIC=C
[5] LC_TIME=English_United States.1252
attached base packages:
[1] stats graphics grDevices utils datasets methods base
other attached packages:
[1] graphite_1.2.0 AnnotationDbi_1.18.0 Biobase_2.16.0
[4] BiocGenerics_0.2.0 RSQLite_0.11.1 DBI_0.2-5
[7] graph_1.34.0
loaded via a namespace (and not attached):
[1] IRanges_1.14.2 org.Hs.eg.db_2.7.1 stats4_2.15.0 tools_2.15.0
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