[BioC] using timecourse package with non-replicated time course

[Johannes Meisig]

Thanks a lot for the quick answers!

Best,
Johannes

Paul Leo wrote:
> Try mfuzz for time course with no replicates
> 
> Cheers
> Paul
> 
> 
> 
> 
> -----Original Message-----
> *From*: Yu Chuan Tai <yuchuan at stat.berkeley.edu 
> <mailto:Yu%20Chuan%20Tai%20%3cyuchuan at stat.berkeley.edu%3e>>
> *To*: Johannes Meisig <j.meisig at biologie.hu-berlin.de 
> <mailto:Johannes%20Meisig%20%3cj.meisig at biologie.hu-berlin.de%3e>>
> *Cc*: bioconductor at r-project.org <bioconductor at r-project.org 
> <mailto:%22bioconductor at r-project.org%22%20%3cbioconductor at r-project.org%3e>>
> *Subject*: Re: [BioC] using timecourse package with non-replicated time 
> course
> *Date*: Fri, 15 Jul 2011 12:02:07 +1000
> 
> Hi Johannes,
> 
> Thanks for your interest in timecourse. However, the current timecourse 
> only works for developmental longitudinal time course data *with* 
> replicates. Therefore, it doesn't work for your data.
> 
> Hope this helps.
> 
> Best,
> Yu Chuan
> 
> On Thu, 14 Jul 2011, Johannes Meisig wrote:
> 
>> Hi,
>>
>> I have a developmental microarray time course with 18 time points under
>> one biological condition but no replicates. I would like to rank genes
>> in order of non-constancy.
>>
>> The timecourse package seems well suited to this analysis. However, in
>> the documentation it says nothing about the no replicate case. In Tai
>> and Speed(1), it seems that the method still works in this special case.
>>   Does anyone know if the timecourse package can be used in this case?
>>
>> Thanks a lot,
>> Johannes
>>
>> (1)
>> Tai and Speed, A Multivariate Empirical Bayes Statistic for Replicated
>> Microarray Time Course Data, The Annals of Statistics, 34, 2006
>>
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