[BioC] merged affy 430 A&B

[James W. MacDonald]

Hi Yongde,

On 4/5/2011 11:53 AM, YBao wrote:
> Hi all,
>
> I wonder if someone has done this -- merging the A set and B set of
> Affy Mouse chip 430 into one data set so as to facilitate further
> analysis such as lima. Some pointers will be appreciated.

I don't see much to gain here by combining. There is AFAIK not much 
overlap between the two (and you certainly don't want to get into the 
business of combining probesets from different chips). You would gain 
some small precision in the overall variability estimate used in limma, 
but otherwise just running separate analyses seems easiest.

Best,

Jim


>
> Thanks
>
> Yongde Bao
> University of Virginia
>
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-- 
James W. MacDonald, M.S.
Biostatistician
Douglas Lab
University of Michigan
Department of Human Genetics
5912 Buhl
1241 E. Catherine St.
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