[BioC] Validated miRNAs revisited

[michael watson (IAH-C)]

Tarbase and miRecords are the only databases of validated targets I know of. MirWalk has a validated section but I think it comes from text mining.
________________________________________
From: bioconductor-bounces at stat.math.ethz.ch [bioconductor-bounces at stat.math.ethz.ch] On Behalf Of mauede at alice.it [mauede at alice.it]
Sent: 01 May 2010 06:11
To: Bioconductor  List
Subject: [BioC] Validated miRNAs revisited

I apologize for asking again the same question I asked some months ago.
The reason is that  a question has been raised recently by people I work with.
The question stemmed from the double meaning of the word "validated" with reference to miRNAs.
Some time ago I downloaded the Fasta files "mature.fa" and "matureStart.fa" (the latter cannot be
found any more).
I meant to get miRNAs that have been experimentally validated against (binding to) some gene targets.
I  used the dat set "hsTargets" avaiilable with Bioconductor to find the matching miRNA-terget pairs.

The question arisen is: "are the nmiRNAs I got just predicted by some code (miRanda or the like) or have they been experimentally validated" ?

I would appreciate your comments.

Thank you in advance
Maura


tutti i telefonini TIM!


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