[BioC] some questions about RNAi hit selection

[Rajarshi Guha]

On Jul 2, 2009, at 6:50 PM, Thomas Hampton wrote:

> Other people may not view your results the same way, and they may need
> independent verification of your effect in some other test, at test  
> that would
> not suffer from the same sort of multiple hypothesis burden as your  
> initial screen.
>
> In my own experience, these independent verifications generally pan  
> out, and
> the issue of P value correction in the initial screen becomes a moot  
> point. I am hoping
> an independent test of some sort is not out of the question.

Thanks for the pointers - yes, there will be a second, followup screen  
and at this point I'm trying to decide whether we should reduce the  
number of genes to look at using p-value correction or start of with a  
larger pool (not doing correction) and use other information to then  
reduce it.

Thanks,

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