[BioC] p.adjust returns one uniform value

Benjamin Otto b.otto at uke.uni-hamburg.de
Tue Sep 4 17:23:20 CEST 2007


Hi,

I'm just sticking on a strange problem. For a set of p-values a correction
via p.adjust should be calculated. Strangely the function returns one
uniform "adjusted p-value" for all genes although the range of the raw
p-values goes from 0.00043 to 0.99. For BH it is something around 0.996 and
for holm, bonferroni etc. it is 1.

The function produces nice values for the examples and I used to use the
function frequently before without ever observing such behaviour. Any
suggestions?

Benjamin


R version 2.5.0 (2007-04-23) 
i386-pc-mingw32 

locale:
LC_COLLATE=English_United States.1252;LC_CTYPE=English_United
States.1252;LC_MONETARY=English_United
States.1252;LC_NUMERIC=C;LC_TIME=English_United States.1252

attached base packages:
[1] "stats"     "graphics"  "grDevices" "utils"     "datasets"  "methods"
"base"     

other attached packages:
mouse4302 
 "1.16.0"

======================================
Benjamin Otto
University Hospital Hamburg-Eppendorf
Institute For Clinical Chemistry
Martinistr. 52
D-20246 Hamburg

Tel.: +49 40 42803 1908
Fax.: +49 40 42803 4971
======================================



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