[BioC] About between-array normalization in limma

[Simon Lin]

Sean Davis Wrote:
>The rule-of-thumb is that if you are working with two-color data and
>using ratios only, then you probably do not need between-array
>normalization.

What is the rationale behind this claim? Is it because the common ref 
channel serves as kind of internal calibration control already?

Seems that the current recommendation of normalization is on the less 
agreesive side?

-Simon